Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines

作者:Zhikui Cheng Ge Sun Wei Guo Yayun Huang Weihua Sun Fei Zhao Kanghong Hu

摘要:Hepatitis B virus(HBV) infection is one of the most serious and prevalent viral diseases in the world. Although several anti-HBV drugs have been used clinically, their side and adverse effects limit treatment efficacy. Therefore, it is necessary to identify novel potential anti-HBV agents. The flavonol quercetin has shown activity against some retroviruses, but its effect on HBV remains unclear. In the present study, quercetin was incubated with Hep G2.2.15 cells, as well as Hu H-7 cells transfected with an HBV plasmid. Quercetin was shown to significantly reduce Hepatitis B surface antigen(HBs Ag) and Hepatitis B e antigen(HBe Ag), secretion and HBV genomic DNA levels in both cell lines. In addition, co-incubation with lamivudine(3TC), entecavir(ETV), or adefovir(Ade) further enhanced the quercetin-induced inhibition of HBV replication. This inhibition was partially associated with decreased heat shock proteins and HBV transcription levels. The results indicate that quercetin inhibited HBV antigen secretion and genome replication in human hepatoma cell lines, which suggests that quercetin may be a potentially effective anti-HBV agent.

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关键词:
  • hepatitis
  • b
  • quercetin
  • flavonol
  • antivira

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期刊名称:中国病毒学

期刊级别:SCI期刊

期刊人气:3170

杂志介绍:
主管单位:中国科学院
主办单位:中国科学院武汉病毒研究所;中国微生物学会
出版地方:湖北
快捷分类:生物
国际刊号:1674-0769
国内刊号:42-1760/Q
邮发代号:38-351
创刊时间:1986
发行周期:双月刊
期刊开本:A4
下单时间:1-3个月
复合影响因子:0.6
综合影响因子:0.582