医用生物力学杂志 北大期刊 CSCD期刊 统计源期刊

医用生物力学 2010年第S1期杂志 文档列表

A 3-D in vitro tumor model for investigation of bacteria-mediated gene delivery1-2

摘要：Introduction Cancer is an attractive target of gene therapy and currently represents the disease in most clinical trials[1]. Strategies for cancer gene therapy include: (1) stimulation of immune responses to tumor cells,(2) delivery of specific enzymes to

生物力学在软组织修复中的应用3-6

摘要：软组织损伤是指由于肌肉、肌腱、筋膜和韧带等承受超负荷活动引起不同程度的纤维断裂或由于积累性损伤或由于软组织无菌性炎症所导致的一系列临床症状,主要表现为疼痛、肿胀和局部活动障碍。随着机械化程度和生活水平的迅速提高,因交通事故和运动等原因造成的软组织损伤发生率明显增多。同时由于致

我国生物力学研究发展三十年7-8

摘要：生物力学(biomechanics)是研究生命体运动和变形的学科,主要通过生物学与力学原理方法的有机结合,认识生命过程的规律,解决生命与健康领域的科学问题。上世纪70年代末,在现代生物力学的创始人冯

Real-time observation of integrin bending/unbending conformational changes on living cells9-10

摘要：Introduction Integrins are a large family of adhesion molecules broadly expressed on the surface of a wide variety of cells as heterodimers. Binding of integrins to ligands provides not only mechanical anchorage for the cell to another cell or extracellular

生物力学在医疗器械设计和跳伞着陆防护中的应用11-12

摘要：前言生物力学是研究生命体运动和变形的学科,主要通过生物学与力学原理方法的有机结合,认识生命过程的规律,解决生命与健康领域的科学问题。生物力学与医学和生物学各门类的交叉,形成了生物力学分支学

Mechanochemical mechanisms of embryonic stem cell pluripotency and differentiation13-13

摘要：Embryonic stem (ES) cell biology is attracting much attention in cell biology because of their pluripotent behaviors and potential therapeutic applications. However,what maintains ES cell pluripotency and what triggers ES cell differentiation

p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly16-17

摘要：Introduction Vascular endothelial (VE)-cadherin is localized to the endothelial borders and the adherens junctions,which are regulated by changes in mitogen activated protein kinases (MAPK),GTPases,and intracellular calcium. We previously showed

Multi-level biomechanical models for rehabilitation engineering18-19

摘要：Rehabilitation engineering aims in the upmost degree to restore the lost functions for those persons with physical disability. Biomechanical modeling has been widely used for different purposes in rehabilitation engineering to understand the bio-

Nanofibrous scaffolds for the regeneration of nervous tissue20-21

摘要：Introductons The biophysical organization of extracellular matrix (ECM) plays an important role in tissue morphogenesis,remodeling and functions. In many types of tissues,e. g. ,blood vessel,nerve,heart,muscle,tendon and ligament,ECM has aniso-

钙火花的生物力学研究25-26

摘要：钙离子是最古老的细胞信使之一,调节着从激素分泌到肌肉收缩、从神经信号传递到学习记忆、从基因表达到蛋白磷酸化、从细胞生长分化到死亡等等重要生命过程。但钙离子为什么能呈现如此广谱的生物学

Molecular engineering and live-cell imaging in mechanobiology27-27

摘要：Cells in the body are exposed to physiological and pathophysiological stimuli that encompass both chemical and mechanical factors,which coordinately modulate cellular functions. Compared to the large amount of information on cellular re-

Liquid crystal model of vesicles under electromechanical fields28-29

摘要：Introduction Recently,much attention has been attracted to various phenomena and processes associated with cells and vesicles in electric fields,e.g. ,electroporation,electrofusion,electrophoresis,electro-deformation and rotation. Cells continuously

Chemical and physical regulations of airway smooth muscle cells and their implications to asthma pathogenesis33-35

摘要：Introduction Although pathogenesis of asthma is still a major challenge in medical science,it is generally agreed that both structural and functional alterations of airway smooth muscle (ASM) are the common final pathway responsible for the excessive con-

Mechanical instability of veins under internal pressure36-37

摘要：Introduction Tortuous veins are often seen in the retina,cerebrum,and human legs. Venous tortuosity may affect blood flow and the wall remodeling process,both of which are associated with venous diseases. It has been shown that tortuous or vari-

力学刺激促进骨髓多能间充质基质细胞向韧带细胞、软骨细胞和心肌样细胞分化初探38-40

摘要：前言为了规范MSC的学术命名,2006年,国际细胞治疗协会(ISCT)间充质和组织干细胞委员会(the Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy)推荐[1],将体外培养的

In vivo and in silico biodynamic studies of cruciate ligament injuries41-43

摘要：Introduction Studies of musculoskeletal structure-function relationships and how they are affected by injuries have primarily relied on in vitro and in vivo methods. The limitations of in vitro studies continue to pose a formidable obstacle in translating research

The crosstalk between endothelial cells and vascular smooth muscle cells during low shear stress:a proteomic-based approach44-46

摘要：Instruction Shear stress,caused by the parallel frictional drag force of blood flow,is a biomechanical force which plays an important role in the control of blood vessels growth and functions [1]. Clinical researches had found out that atherosclerotic le-

Mitral valve mechanics and function47-48

摘要：Introduction Progress in valve repair techniques is improving the quality of life of patients with mitral valve regurgitation and make valve repair preferred over valve replacement. However,the major hurdle of valve repair development is mitral valve me-