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摘要:Integrins are a large family of adhesion molecules broadly expressed on the surface of a wide variety of cells as heterodimers.Binding of integrins to ligands provides anchorage and signals for the cell,making them prime candidates for mechanosensing molecules.To elucidate how force regulates integrin/ligand dissociation,we used molecular mechanics experiments to
摘要:The development and maintenance of an abundant blood supply is essential for the healing of wound and neoplastic tissues.Angiogenesis,the development of new vessels from adjacent capillary networks,plays an important role in physiologic and as well as in pathologic
摘要:Integrins are heterodimers that mediate cell adhesion and transduce signals bidirectionally across the cell membrane.Integrins often exist in low affinity(or inactive) states for ligand